Isavuconazole therapy in an FLT3 mutated acute myeloid leukemia patient receiving midostaurin: A case report.

doi:10.1177/1078155218764257

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Article

Isavuconazole therapy in an FLT3 mutated acute myeloid leukemia patient receiving midostaurin: A case report.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners - 1 Jun 2019

Tollkuci Eris

Abstract excerpt

Midostaurin is the first approved FMS-related tyrosine kinase 3 (FLT3) inhibitor indicated for FLT3 mutated acute myeloid leukemia. Midostaurin is a major cytochrome P450 3A4 (CYP3A4) substrate. Coadministration with a strong CYP3A4 inhibitor or inducer can lead to a potential increase or decreas...

Topics

Adult
Antineoplastic Agents
Cytochrome P-450 CYP3A Inhibitors
Humans
Leukemia, Myeloid, Acute
Male
Mutation
Nitriles
Protein Kinase Inhibitors
Pyridines
Staurosporine
Triazoles
fms-Like Tyrosine Kinase 3

Source

Open in PubMed

Identifiers

PMID: 29558838
DOI: 10.1177/1078155218764257

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-29558838-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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