Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults.

doi:10.1073/pnas.1706096114

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Article

Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults.

Proceedings of the National Academy of Sciences of the United States of America - 3 Apr 2018

Perkins Bradley A, Caskey C Thomas, Brar Pamila, Dec Eric, Karow David S, Kahn Andrew M, Hou Ying-Chen Claire, Shah Naisha, Boeldt Debbie, Coughlin Erin, Hands Gabby, Lavrenko Victor, Yu James, Procko Andrea, Appis Julia, Dale Anders M, Guo Lining, Jönsson Thomas J, Wittmann Bryan M, Bartha Istvan, Ramakrishnan Smriti, Bernal Axel, Brewer James B, Brewerton Suzanne, Biggs William H, Turpaz Yaron, Venter J Craig

Abstract excerpt

Reducing premature mortality associated with age-related chronic diseases, such as cancer and cardiovascular disease, is an urgent priority. We report early results using genomics in combination with advanced imaging and other clinical testing to proactively screen for age-related chronic disease risk among adults. We enrolled active, symptom-free adults in a study of screening for age-related chronic diseases...

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Identifiers

PMID: 29555771
DOI: 10.1073/pnas.1706096114
PMCID: PMC5889622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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