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Article

NTRK Fusions Define a Novel Uterine Sarcoma Subtype With Features of Fibrosarcoma.

The American journal of surgical pathology - 1 Jun 2018

Chiang Sarah, Cotzia Paolo, Hyman David M, Drilon Alexander, Tap William D, Zhang Lei, Hechtman Jaclyn F, Frosina Denise, Jungbluth Achim A, Murali Rajmohan, Park Kay J, Soslow Robert A, Oliva Esther, Iafrate A John, Benayed Ryma, Ladanyi Marc, Antonescu Cristina R

Abstract excerpt

Tropomyosin receptor kinase (Trk) inhibitors have shown high response rates in patients with tumors harboring NTRK fusions. We identified 4 NTRK fusion-positive uterine sarcomas that should be distinguished from leiomyosarcoma and undifferentiated uterine sarcoma. NTRK rearrangements were detected by fluorescence in situ hybridization (FISH) and/or targeted RNA or DNA sequencing in 4 undifferentiated uterine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29553955
DOI: 10.1097/PAS.0000000000001055
PMCID: PMC6764747

Genes

NTRK1
NTRK3
LMNA
RBPMS
TPM3
TPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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