Article
Haplotype analysis of XRCC1 gene polymorphisms and the risk of thyroid carcinoma.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology - 1 Jan 2000
Bashir Kashif, Sarwar Romana, Fatima Shazia, Saeed Soma, Mahjabeen Ishrat, Akhtar Kayani Mahmood
Abstract excerpt
PURPOSE: Variants in DNA repair genes may alter the repair mechanisms that make the persons vulnerable to DNA damage. These polymorphic variants in the DNA repair pathway genes, such as XRCC1, have been associated with susceptibility of several types of cancer including thyroid cancer. This study was designed to explore the link between XRCC1 polymorphisms and modulation of thyroid cancer risk. METHODS: Our study...
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