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Article

Airway pathological heterogeneity in asthma: Visualization of disease microclusters using topological data analysis.

The Journal of allergy and clinical immunology - 1 Nov 2018

Siddiqui Salman, Shikotra Aarti, Richardson Matthew, Doran Emma, Choy David, Bell Alex, Austin Cary D, Eastham-Anderson Jeffrey, Hargadon Beverley, Arron Joseph R, Wardlaw Andrew, Brightling Christopher E, Heaney Liam G, Bradding Peter

Abstract excerpt

BACKGROUND: Asthma is a complex chronic disease underpinned by pathological changes within the airway wall. How variations in structural airway pathology and cellular inflammation contribute to the expression and severity of asthma are poorly understood. OBJECTIVES: Therefore we evaluated pathological heterogeneity using topological data analysis (TDA) with the aim of visualizing disease clusters and...

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Identifiers

PMID: 29550052
DOI: 10.1016/j.jaci.2017.12.982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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