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Pharmacological inhibition of arachidonate 15-lipoxygenase protects human spermatozoa against oxidative stress†

13 Mar 2018

Abstract excerpt

One of the leading causes of male infertility is defective sperm function, a pathology that commonly arises from oxidative stress in the germline. Lipid peroxidation events in the sperm plasma membrane result in the generation of cytotoxic aldehydes such as 4-hydroxynonenal (4HNE), which accentuate the production of reactive oxygen species (ROS) and cause cellular damage. One of the key enzymes involved in the...

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PMID: 29546268
DOI: 10.1093/biolre/ioy058

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