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Alpha lipoic acid reverses the negative effect of LPS on mouse spermatozoa and developmental competence of resultant embryos in vitro

20 Feb 2019

Abstract excerpt

BACKGROUND: Reproductive toxicity of lipopolysaccharide (LPS) on spermatozoa is well established. OBJECTIVE: The aim of the present study was to show the potential benefits of alpha lipoic acid (ALA) as a strong antioxidant in alleviating the reproductive toxicity of LPS. MATERIALS AND METHODS: Sperm cells and cumulus-oocyte complexes (COCs) were collected from healthy NMRI mice (body weights ranged from 25 to 35...

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PMID: 30786163
DOI: 10.1111/andr.12596

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