Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Electrophilic Aldehydes Generated by Sperm Metabolism Activate Mitochondrial Reactive Oxygen Species Generation and Apoptosis by Targeting Succinate Dehydrogenase

1 Aug 2012

Abstract excerpt

Oxidative stress is a major cause of defective sperm function in cases of male infertility. Such stress is known to be associated with high levels of superoxide production by the sperm mitochondria; however, the causes of this aberrant activity are unknown. Here we show that electrophilic aldehydes such as 4-hydroxynonenal (4HNE) and acrolein, generated as a result of lipid peroxidation, target the mitochondria...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pesticide Exposure and Toxicity
Share to Reproductive Biology and Fertility
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22851170
DOI: 10.1074/jbc.m112.366690

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Electrophilic Aldehydes Generated by Sperm Metabolism Activate Mitochondrial Reactive Oxygen Species Generation and Apoptosis by Targeting Succinate DehydrogenasePMID 22851170Read ↗

Molecular Changes Induced by Oxidative Stress that Impair Human Sperm MotilitySemantic proximity Read ↗

Mass Spectrometry Reveals New Insights into the Production of Superoxide Anions and 4‐Hydroxynonenal Adducted Proteins in Human SpermSemantic proximity Read ↗

Reactive Oxygen Species and Sperm Function—In Sickness and In HealthSemantic proximity Read ↗

Definitive Evidence for the Nonmitochondrial Production of Superoxide Anion by Human SpermatozoaSemantic proximity Read ↗

Free radicals, lipid peroxidation and sperm functionSemantic proximity Read ↗

Causes and consequences of apoptosis in spermatozoa; contributions to infertility and impacts on developmentSemantic proximity Read ↗

The Capacitation-Apoptosis Highway: Oxysterols and Mammalian Sperm FunctionSemantic proximity Read ↗

Reactive oxygen species and sperm cellsSemantic proximity Read ↗

Reactive oxygen species and human spermatozoa: physiology and pathologySemantic proximity Read ↗

Pathophysiology of Mitochondrial Dysfunction in Human Spermatozoa: Focus on Energetic Metabolism, Oxidative Stress and ApoptosisSemantic proximity Read ↗

The John Hughes Memorial Lecture: Aspects of Sperm Physiology—Oxidative Stress and the Functionality of Stallion SpermatozoaSemantic proximity Read ↗

Aldehyde Dehydrogenase Plays a Pivotal Role in the Maintenance of Stallion Sperm Motility1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.