Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis.

doi:10.1038/s41598-018-22626-w

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Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis.

Scientific reports - 14 Mar 2018

Pastorino Roberta, Puggina Anna, Carreras-Torres Robert, Lagiou Pagona, Holcátová Ivana, Richiardi Lorenzo, Kjaerheim Kristina, Agudo Antonio, Castellsagué Xavier, Macfarlane Tatiana V, Barzan Luigi, Canova Cristina, Thakker Nalin S, Conway David I, Znaor Ariana, Healy Claire M, Ahrens Wolfgang, Zaridze David, Szeszenia-Dabrowska Neonilia, Lissowska Jolanta, Fabianova Eleonora, Mates Ioan Nicolae, Bencko Vladimir, Foretova Lenka, Janout Vladimir, Brennan Paul, Gaborieau Valérie, McKay James D, Boccia Stefania

Abstract excerpt

With the aim to dissect the effect of adult height on head and neck cancer (HNC), we use the Mendelian randomization (MR) approach to test the association between genetic instruments for height and the risk of HNC. 599 single nucleotide polymorphisms (SNPs) were identified as genetic instruments for height, accounting for 16% of the phenotypic variation. Genetic data concerning HNC cases and controls were...

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PMID: 29540730
DOI: 10.1038/s41598-018-22626-w
PMCID: PMC5852094

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