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Article

Taller height and risk of coronary heart disease and cancer: A within-sibship Mendelian randomization study.

eLife - 18 Mar 2022

Howe Laurence J, Brumpton Ben, Rasheed Humaira, Åsvold Bjørn Olav, Davey Smith George, Davies Neil M

Abstract excerpt

Background: Taller people have a lower risk of coronary heart disease but a higher risk of many cancers. Mendelian randomization (MR) studies in unrelated individuals (population MR) have suggested that these relationships are potentially causal. However, population MR studies are sensitive to demography (population stratification, assortative mating) and familial (indirect genetic) effects. Methods: In this...

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Body Height
Causality
Coronary Disease
Genome-Wide Association Study
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 35302490
DOI: 10.7554/eLife.72984
PMCID: PMC8947759

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