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Article

RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer

13 Mar 2018

Abstract excerpt

Abstract Purpose: Alteration in cell death is a hallmark of cancer. A functional role regulating survival, apoptosis, and necroptosis has been attributed to RIP1/3 complexes. Experimental Design: We have investigated the role of RIP1 and the effects of MC2494 in cell death induction, using different methods as flow cytometry, transcriptome analysis, immunoprecipitation, enzymatic assays, transfections,...

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PMID: 29535128
DOI: 10.1158/1078-0432.ccr-17-3081

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