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Characterization and Mutational Analysis of Two UDP-Galactose 4-Epimerases in Streptococcus pneumoniae TIGR4.

Biochemistry. Biokhimiia - 1 Jan 2018

Chen L L, Han D L, Zhai Y F, Wang J H, Wang Y F, Chen M

Abstract excerpt

Current clinical treatments for pneumococcal infections have many limitations and are faced with many challenges. New capsular polysaccharide structures must be explored to cope with diseases caused by different serotypes of Streptococcus pneumoniae. UDP-galactose 4-epimerase (GalE) is an essential enzyme involved in polysaccharide synthesis. It is an important virulence factor in many bacterial pathogens. In...

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PMID: 29534667
DOI: 10.1134/S0006297918010054

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