Article
MIB-1 Is Required for Spermatogenesis and Facilitates LIN-12 and GLP-1 Activity in Caenorhabditis elegans.
Genetics - 1 May 2018
Ratliff Miriam, Hill-Harfe Katherine L, Gleason Elizabeth J, Ling Huiping, Kroft Tim L, L'Hernault Steven W
Abstract excerpt
Covalent attachment of ubiquitin to substrate proteins changes their function or marks them for proteolysis, and the specificity of ubiquitin attachment is mediated by the numerous E3 ligases encoded by animals. Mind Bomb is an essential E3 ligase during Notch pathway signaling in insects and ver...
Topics
- Alleles
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Gene Expression Regulation, Developmental
- Glucagon-Like Peptide 1
- Loss of Function Mutation
- Mutation
- Phenotype
- Receptors, Notch
- Signal Transduction
- Spermatogenesis
- Ubiquitin-Protein Ligases