Article
Drug-induced xenogenization of tumors: A possible role in the immune control of malignant cell growth in the brain?
Pharmacological research - 1 May 2018
Franzese Ornella, Battaini Fiorenzo, Graziani Grazia, Tentori Lucio, Barbaccia Maria Luisa, Aquino Angelo, Roselli Mario, Fuggetta Maria Pia, Bonmassar Enzo, Torino Francesco
Abstract excerpt
In recent years, immune checkpoint inhibitors (ICpI) have provided the ground to bring tumor immunity back to life thanks to their capacity to afford a real clinical benefit in terms of patient's survival. Essential to ICpI success is the presence of tumor-associated neoantigens generated by non-synonymous mutations, since a direct relationship between mutation load of malignant cells and susceptibility to ICpI...
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