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Article

Conversion of allosteric inhibition to activation in phosphofructokinase by protein engineering.

Nature - 1 Jan 2000

Lau F T, Fersht A R

Abstract excerpt

Many enzymes are subject to allosteric control, often with inhibitors and activators binding to the same effector site. Phosphofructokinase in Escherichia coli is such an enzyme, being inhibited by phosphoenolpyruvate (PEP) and activated by ADP and GDP. How do individual interactions with effectors affect the balance between activation and inhibition, especially when both ligands share aspects of the same binding...

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Identifiers

PMID: 2952886
DOI: 10.1038/326811a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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