Article
Endothelial nitric oxide synthase gene polymorphism is associated with systemic lupus erythematosus.
The Journal of rheumatology - 1 Nov 2004
Serrano Norma C, Páez Carolina, Correa Paula A, Anaya Juan-Manuel
Abstract excerpt
OBJECTIVE: In systemic lupus erythematosus (SLE), endothelial nitric oxide synthase (eNOS) gene locus has been found to be suggestive of linkage with disease, nitric oxide (NO) is produced in significant amounts, and endothelial cell dysfunction is observed. eNOS gene polymorphism may affect both the synthesis of eNOS protein and its enzymatic activity. We examined the influence of eNOS gene polymorphisms on...
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