Article
Reduced myocardial 123-iodine metaiodobenzylguanidine uptake: a prognostic marker in familial amyloid polyneuropathy.
Circulation. Cardiovascular imaging - 1 Sept 2013
Coutinho Maria C Azevedo, Cortez-Dias Nuno, Cantinho Guilhermina, Conceição Isabel, Oliveira António, Bordalo e Sá Armando, Gonçalves Susana, Almeida Ana G, de Carvalho Mamede, Diogo António Nunes
Abstract excerpt
BACKGROUND: Transthyretin familial amyloid polyneuropathy is a hereditary form of amyloidosis characterized by sensorimotor and autonomic neuropathy, cardiac conduction defects, and infiltrative cardiomyopathy. Previous studies have suggested that myocardial sympathetic denervation assessed by 123-iodine metaiodobenzylguanidine (MIBG) imaging occurs early in disease progression. However, its prognostic...
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