Article
Creutzfeldt astrocytes may be seen in IDH-wildtype glioblastoma and retain expression of DNA repair and chromatin binding proteins.
Brain pathology (Zurich, Switzerland) - 1 Nov 2018
Ballester Leomar Y, Boghani Zain, Baskin David S, Britz Gavin W, Olsen Randall, Fuller Gregory N, Powell Suzanne Z, Cykowski Matthew D
Abstract excerpt
Astrocytes with multiple micronuclei ("Creutzfeldt cells") in a brain biopsy are classically associated with demyelinating disease. However, glioblastoma may also have prominent Creutzfeldt astrocytes, along with granular mitoses. Therefore, Creutzfeldt cells may raise the diagnostic dilemma of high-grade glioma vs tumefactive demyelination. While cases of glioblastoma (GBM) with Creutzfeldt astrocytes have been...
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