Article
The Amount of Melanin Influences p16 Loss in Spitzoid Melanocytic Lesions: Correlation With CDKN2A Status by FISH and MLPA.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Jul 2019
Martinez Ciarpaglini Carolina, Gonzalez Jose, Sanchez Beatriz, Agusti Jaime, Navarro Lara, Nieto Gema, Monteagudo Carlos
Abstract excerpt
AIMS: The risk assessment of spitzoid lesions is one of the most difficult challenges in dermatopathology practice. In this regard, the loss of p16 expression and the homozygous deletion of CDKN2A, have been pointed in the literature as reliable indicators of high risk. However, these findings are poorly reproducible, and the molecular bases underlying the loss of p16 expression remain unclear. We aimed to...
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