Article
Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2018
Haynes Jennifer, McKee Trevor D, Haller Andrew, Wang Yadong, Leung Cherry, Gendoo Deena M A, Lima-Fernandes Evelyne, Kreso Antonija, Wolman Robin, Szentgyorgyi Eva, Vines Douglass C, Haibe-Kains Benjamin, Wouters Bradly G, Metser Ur, Jaffray David A, Smith Myles, O'Brien Catherine A
Abstract excerpt
Purpose: Cancer-initiating cells (C-IC) have been described in multiple cancer types, including colorectal cancer. C-ICs are defined by their capacity to self-renew, thereby driving tumor growth. C-ICs were initially thought to be static entities; however, recent studies have determined these cells to be dynamic and influenced by microenvironmental cues such as hypoxia. If hypoxia drives the formation of C-ICs,...
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