Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data

Abstract excerpt

OBJECTIVE: In this study, we sought to refine histologic scoring of rheumatoid arthritis (RA) synovial tissue by training with gene expression data and machine learning. METHODS: Twenty histologic features were assessed in 129 synovial tissue samples (n = 123 RA patients and n = 6 osteoarthritis [OA] patients). Consensus clustering was performed on gene expression data from a subset of 45 synovial samples....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gene expression and cancer classification
• Share to Rheumatoid Arthritis Research and Therapies
• Share to Spondyloarthritis Studies and Treatments