N-glycosylation of Viral E Protein Is the Determinant for Vector Midgut Invasion by Flaviviruses

Abstract excerpt

ABSTRACT Transmission of flaviviruses by hematophagous insects such as mosquitoes requires acquisition of the virus during blood feeding on the host, with midgut as the primary infection site. Here, we report that N-glycosylation of the E protein, which is conserved among most flaviviruses, is critical for the Zika virus (ZIKV) to invade the vector midgut by inhibiting the reactive oxygen species (ROS) pathway of...

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