Article
Human papilloma virus genotyping for the cross-sectional and longitudinal probability of developing cervical intraepithelial neoplasia grade 2 or more.
International journal of cancer - 15 Jul 2018
Del Mistro Annarosa, Adcock Rachael, Carozzi Francesca, Gillio-Tos Anna, De Marco Laura, Girlando Salvatore, Rizzolo Raffaella, Frayle Helena, Trevisan Morena, Sani Cristina, Burroni Elena, Giorgi Rossi Paolo, Cuzick Jack, Ronco Guglielmo
Abstract excerpt
Human papilloma virus (HPV) testing is more sensitive but less specific than cytology. We evaluated stand-alone genotyping as a possible triage method. During a multicentre randomised controlled trial comparing HPV testing to conventional cytology, HPV-positive women were referred to colposcopy and followed up if no high-grade lesion was detected. HPV-positive samples were genotyped by GP5+/GP6+ primed polymerase...
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