Article
Mutation in the Zebrafish cct2 Gene Leads to Abnormalities of Cell Cycle and Cell Death in the Retina: A Model of CCT2-Related Leber Congenital Amaurosis.
Investigative ophthalmology & visual science - 1 Feb 2018
Minegishi Yuriko, Nakaya Naoki, Tomarev Stanislav I
Abstract excerpt
Purpose: The compound heterozygous mutations in the β subunit of chaperonin containing TCP-1 (CCT), encoded by CCT2, lead to the Leber congenital amaurosis (LCA). In this study, a cct2 mutant line of zebrafish was established to investigate the role of CCT2 mutations in LCA in vertebrates. Methods: A cct2 mutant zebrafish line was produced using the CRISPR-Cas9 system. Changes in the eyes of developing wild-type...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.