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Article

CCTalpha and CCTdelta chaperonin subunits are essential and required for cilia assembly and maintenance in Tetrahymena.

PloS one - 18 May 2010

Seixas Cecilia, Cruto Teresa, Tavares Alexandra, Gaertig Jacek, Soares Helena

Abstract excerpt

BACKGROUND: The eukaryotic cytosolic chaperonin CCT is a hetero-oligomeric complex formed by two rings connected back-to-back, each composed of eight distinct subunits (CCTalpha to CCTzeta). CCT complex mediates the folding, of a wide range of newly synthesised proteins including tubulin (alpha, beta and gamma) and actin, as quantitatively major substrates. METHODOLOGY/PRINCIPAL FINDINGS: We disrupted the genes...

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Identifiers

PMID: 20502701
DOI: 10.1371/journal.pone.0010704
PMCID: PMC2872681

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Source receipt: pubmed, retrieved 7 Sept 2026.

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