Article
Generation and characterization of Ccdc28b mutant mice links the Bardet-Biedl associated gene with mild social behavioral phenotypes.
PLoS genetics - 1 Jun 2022
Fabregat Matías, Niño-Rivero Sofía, Pose Sabrina, Cárdenas-Rodríguez Magdalena, Bresque Mariana, Hernández Karina, Prieto-Echagüe Victoria, Schlapp Geraldine, Crispo Martina, Lagos Patricia, Lago Natalia, Escande Carlos, Irigoín Florencia, Badano Jose L
Abstract excerpt
CCDC28B (coiled-coil domain-containing protein 28B) was identified as a modifier in the ciliopathy Bardet-Biedl syndrome (BBS). Our previous work in cells and zebrafish showed that CCDC28B plays a role regulating cilia length in a mechanism that is not completely understood. Here we report the generation of a Ccdc28b mutant mouse using CRISPR/Cas9 (Ccdc28b mut). Depletion of CCDC28B resulted in a mild phenotype....
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