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Article

Candidate-gene based GWAS identifies reproducible DNA markers for metabolic pyrethroid resistance from standing genetic variation in East African Anopheles gambiae.

Scientific reports - 13 Feb 2018

Weetman David, Wilding Craig S, Neafsey Daniel E, Müller Pie, Ochomo Eric, Isaacs Alison T, Steen Keith, Rippon Emily J, Morgan John C, Mawejje Henry D, Rigden Daniel J, Okedi Loyce M, Donnelly Martin J

Abstract excerpt

Metabolic resistance to pyrethroid insecticides is widespread in Anopheles mosquitoes and is a major threat to malaria control. DNA markers would aid predictive monitoring of resistance, but few mutations have been discovered outside of insecticide-targeted genes. Isofemale family pools from a wild Ugandan Anopheles gambiae population, from an area where operational pyrethroid failure is suspected, were genotyped...

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Identifiers

PMID: 29440767
DOI: 10.1038/s41598-018-21265-5
PMCID: PMC5811533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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