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MYL6B, a myosin light chain, promotes MDM2-mediated p53 degradation and drives HCC development

13 Feb 2018

Abstract excerpt

BACKGROUND: Identification of novel MDM2 or p53 binding proteins may reveal undefined oncogenes, tumor suppressors, signaling pathways and possible treatment targets. METHODS: By means of immunoprecipitation and Mass Spectrometry analysis, we aimed to identify novel regulators of the MDM2-p53 pathway. We further clarified the impact of MYL6B on the p53 protein level and on the process of apoptosis. We also...

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PMID: 29439719
DOI: 10.1186/s13046-018-0693-7

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