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Article

TRIM52 up-regulation in hepatocellular carcinoma cells promotes proliferation, migration and invasion through the ubiquitination of PPM1A

13 Jun 2018

Abstract excerpt

BACKGROUND: Many tripartite motif (TRIM) family proteins have been reported to be of great importance in the initiation and progression in hepatocellular carcinoma (HCC). However, the biological role and regulatory mechanism of tripartite motif containing 52 (TRIM52) in HCC development and progression are poorly defined. METHODS: dependent 1A (PPM1A), p-Smad2/3 and Smad2/3 levels in HCC tissues and cell lines....

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PMID: 29898761
DOI: 10.1186/s13046-018-0780-9

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