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Article

The Neurotropic Properties of AAV-PHP.B Are Limited to C57BL/6J Mice

2 Feb 2018

Abstract excerpt

Improved delivery of adeno-associated virus (AAV) vectors to the CNS will greatly enhance their clinical utility. Selection of AAV9 variants in a mouse model led to the isolation of a capsid called PHP.B, which resulted in remarkable transduction of the CNS following intravenous infusion. However, we now show here that this enhanced CNS tropism is restricted to the model in which it was selected, i.e., a Cre...

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Identifiers

PMID: 29428298
DOI: 10.1016/j.ymthe.2018.01.018

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