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Article

A Catalytically Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation.

Journal of molecular biology - 16 Mar 2018

Meng Yilin, Ahuja Lalima G, Kornev Alexandr P, Taylor Susan S, Roux Benoît

Abstract excerpt

Tyrosine kinases are enzymes playing a critical role in cellular signaling. Molecular dynamics umbrella sampling potential of mean force computations are used to quantify the impact of activating and inactivating mutations of c-Src kinase. The potential of mean force computations predict that a specific double mutant can stabilize c-Src kinase into an active-like conformation while disabling the binding of ATP in...

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Identifiers

PMID: 29410316
DOI: 10.1016/j.jmb.2018.01.019
PMCID: PMC6279248

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