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Article

Coxsackievirus B1 infections are associated with the initiation of insulin-driven autoimmunity that progresses to type 1 diabetes.

Diabetologia - 1 May 2018

Sioofy-Khojine Amir-Babak, Lehtonen Jussi, Nurminen Noora, Laitinen Olli H, Oikarinen Sami, Huhtala Heini, Pakkanen Outi, Ruokoranta Tanja, Hankaniemi Minna M, Toppari Jorma, Vähä-Mäkilä Mari, Ilonen Jorma, Veijola Riitta, Knip Mikael, Hyöty Heikki

Abstract excerpt

AIMS/HYPOTHESIS: Islet autoimmunity usually starts with the appearance of autoantibodies against either insulin (IAA) or GAD65 (GADA). This categorises children with preclinical type 1 diabetes into two immune phenotypes, which differ in their genetic background and may have different aetiology. The aim was to study whether Coxsackievirus group B (CVB) infections, which have been linked to the initiation of islet...

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PMID: 29404673
DOI: 10.1007/s00125-018-4561-y

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