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Article

SMAD4 feedback regulates the canonical TGF-β signaling pathway to control granulosa cell apoptosis

2 Feb 2018

Abstract excerpt

Canonical TGF-β signals are transduced from the cell surface to the cytoplasm, and then translocated into the nucleus, a process that involves ligands (TGF-β1), receptors (TGFBR2/1), receptor-activated SMADs (SMAD2/3), and the common SMAD (SMAD4). Here we provide evidence that SMAD4, a core component of the canonical TGF-β signaling pathway, regulates the canonical TGF-β signaling pathway in porcine granulosa...

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PMID: 29396446
DOI: 10.1038/s41419-017-0205-2

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