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Article

YfiBNR mediates cyclic di-GMP dependent small colony variant formation and persistence in Pseudomonas aeruginosa.

PLoS pathogens - 12 Mar 2010

Malone Jacob G, Jaeger Tina, Spangler Christian, Ritz Daniel, Spang Anne, Arrieumerlou Cécile, Kaever Volkhard, Landmann Regine, Jenal Urs

Abstract excerpt

During long-term cystic fibrosis lung infections, Pseudomonas aeruginosa undergoes genetic adaptation resulting in progressively increased persistence and the generation of adaptive colony morphotypes. This includes small colony variants (SCVs), auto-aggregative, hyper-adherent cells whose appearance correlates with poor lung function and persistence of infection. The SCV morphotype is strongly linked to elevated...

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Identifiers

PMID: 20300602
DOI: 10.1371/journal.ppat.1000804
PMCID: PMC2837407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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