Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Marked functional recovery and imaging response of refractory optic pathway glioma to BRAFV600E inhibitor therapy: a report of two cases.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery - 1 Apr 2018

Upadhyaya Santhosh A, Robinson Giles W, Harreld Julie H, Klimo Paul D, Hoehn Mary Ellen, Orr Brent A, Qaddoumi Ibrahim A

Abstract excerpt

BACKGROUND: Despite appropriate therapeutic interventions, progressive optic pathway glioma (OPG) in children may result in loss of vision and other neurologic morbidities. Molecularly targeted therapy against the MAP kinase pathway holds promise in improving outcomes while resulting in lower treatment-related toxicities. We report two children with refractory OPG who had a substantial and early reversal of their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infant

Share to Magnetic Resonance Imaging

Share to Proto-Oncogene Proteins B-raf

Share to Recovery of Function

Share to Treatment Outcome

Share to Vemurafenib

Source

Open in PubMed Open full text

Identifiers

PMID: 29392423
DOI: 10.1007/s00381-018-3739-4
PMCID: PMC5857244

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Marked functional recovery and imaging response of refractory optic pathway glioma to BRAFV600E inhibitor therapy: a report of two cases.PMID 29392423Read ↗

Phase II Weekly Vinblastine for Chemotherapy-Naïve Children With Progressive Low-Grade Glioma: A Canadian Pediatric Brain Tumor Consortium Study.Semantic proximity Read ↗

Response of recurrent BRAFV600E mutated ganglioglioma to Vemurafenib as single agent.Semantic proximity Read ↗

Neurofibromatosis type 1-associated optic pathway gliomas: pathogenesis and emerging treatments.Semantic proximity Read ↗

Visual acuity of children treated with chemotherapy for optic pathway gliomas.Semantic proximity Read ↗

Dabrafenib desensitization after a vemurafenib-induced hypersensitivity reaction in a pediatric patient with BRAFV600E mutant pilocytic astrocytomaSemantic proximity Read ↗

Recent advances in optic nerve glioma with a focus on the young patient.Semantic proximity Read ↗

Complete clinical regression of a BRAF V600E-mutant pediatric glioblastoma multiforme after BRAF inhibitor therapy.Semantic proximity Read ↗

Salvage therapy with BRAF inhibitors for recurrent pleomorphic xanthoastrocytoma: a retrospective case series.Semantic proximity Read ↗

Impact of BRAF/MEK inhibitor on BRAF V600E-mutated pilocytic astrocytoma.Semantic proximity Read ↗

Response to combined BRAF/MEK inhibition in adult BRAF V600E mutant spinal pilocytic astrocytoma.Semantic proximity Read ↗

Phase II study of vemurafenib in children and young adults with tumors harboring BRAF V600 mutations: NCI-COG pediatric MATCH trial (APEC1621) Arm G.Semantic proximity Read ↗

Combined Proton and Photon Radiotherapy for Orbital Granular Cell Tumor: A Case Report and Review of the LiteratureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.