Article
Dabrafenib desensitization after a vemurafenib-induced hypersensitivity reaction in a pediatric patient with BRAFV600E mutant pilocytic astrocytoma
2020-10-16
Abstract excerpt
BRAFV600E inhibitor therapy, either alone or in combination with a MEK inhibitor, demonstrates positive responses in pediatric patients with gliomas harboring the BRAFV600E mutation. However, rare but life-threatening hypersensitivity reactions to BRAFV600E inhibitors may result in abrupt and permanent discontinuation of therapy. We report successful desensitization, tolerance, and continued response to an alterna...
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Identifiers and source
- Literature Corpus work
- 8dd00bdc-3c9e-57d3-8221-a02180a06d11
- DOI
- 10.22541/au.160288168.85122740/v1