Article
Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations.
Thorax - 1 May 2018
Mayhew David, Devos Nathalie, Lambert Christophe, Brown James R, Clarke Stuart C, Kim Viktoriya L, Magid-Slav Michal, Miller Bruce E, Ostridge Kristoffer K, Patel Ruchi, Sathe Ganesh, Simola Daniel F, Staples Karl J, Sung Ruby, Tal-Singer Ruth, Tuck Andrew C, Van Horn Stephanie, Weynants Vincent, Williams Nicholas P, Devaster Jeanne-Marie, Wilkinson Tom M A
Abstract excerpt
BACKGROUND: Alterations in the composition of the lung microbiome associated with adverse clinical outcomes, known as dysbiosis, have been implicated with disease severity and exacerbations in COPD. OBJECTIVE: To characterise longitudinal changes in the lung microbiome in the AERIS study (Acute Exacerbation and Respiratory InfectionS in COPD) and their relationship with associated COPD outcomes. METHODS: We...
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