Article
Eculizumab induces long-term remission in recurrent post-transplant HUS associated with C3 gene mutation.
Pediatric nephrology (Berlin, Germany) - 1 Apr 2011
Al-Akash Samhar I, Almond P Stephen, Savell Van H, Gharaybeh Salam I, Hogue Cris
Abstract excerpt
A 15-year-old male patient developed atypical hemolytic uremic syndrome (aHUS) at 16 months of age leading to end-stage renal disease. The family history was suggestive of autosomal dominant aHUS, and he was more recently found to have a C3 heterozygous gene mutation (1835C>T mutation in exon 14, which determines the amino-acidic substitution R570W) with no other complement abnormalities. He had two renal...
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