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Article

Viral protein Nef is detected in plasma of half of HIV-infected adults with undetectable plasma HIV RNA

24 Jan 2018

Abstract excerpt

OBJECTIVE: To address the role of translationally active HIV reservoir in chronic inflammation and non-AIDS related disorders, we first need a simple and accurate assay to evaluate viral protein expression in virally suppressed subjects. DESIGN: We optimized an HIV Nef enzyme-linked immunosorbent assay (ELISA) and used it to quantify plasma Nef levels as an indicator of the leaky HIV reservoir in an HIV-infected...

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PMID: 29364927
DOI: 10.1371/journal.pone.0191613

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