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Article

CCR5 Expression Influences the Progression of Human Breast Cancer in a p53-dependent Manner

3 Nov 2003

Abstract excerpt

Chemokines are implicated in tumor pathogenesis, although it is unclear whether they affect human cancer progression positively or negatively. We found that activation of the chemokine receptor CCR5 regulates p53 transcriptional activity in breast cancer cells through pertussis toxin-, JAK2-, and p38 mitogen-activated protein kinase-dependent mechanisms. CCR5 blockade significantly enhanced proliferation of...

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PMID: 14597737
DOI: 10.1084/jem.20030580

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