Gene Expression Signatures Characterized by Longitudinal Stability and Interindividual Variability Delineate Baseline Phenotypic Groups with Distinct Responses to Immune Stimulation.

doi:10.4049/jimmunol.1701099

Article

Gene Expression Signatures Characterized by Longitudinal Stability and Interindividual Variability Delineate Baseline Phenotypic Groups with Distinct Responses to Immune Stimulation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2018

Scheid Adam D, Van Keulen Virginia P, Felts Sara J, Neier Steven C, Middha Sumit, Nair Asha A, Techentin Robert W, Gilbert Barry K, Jen Jin, Neuhauser Claudia, Zhang Yuji, Pease Larry R

Abstract excerpt

Human immunity exhibits remarkable heterogeneity among individuals, which engenders variable responses to immune perturbations in human populations. Population studies reveal that, in addition to interindividual heterogeneity, systemic immune signatures display longitudinal stability within individuals, and these signatures may reliably dictate how given individuals respond to immune perturbations. We hypothesize...

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Gene Expression Signatures Characterized by Longitudinal Stability and Interindividual Variability Delineate Baseline Phenotypic Groups with Distinct Responses to Immune Stimulation.

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