Profiling of the ADP‐Ribosylome in Living Cells

Abstract excerpt

Abstract Post‐translational modification (PTM) with ADP‐ribose and poly(ADP‐ribose) using nicotinamide adenine dinucleotide (NAD + ) as substrate is involved in the regulation of numerous cellular pathways in eukaryotes, notably the response to DNA damage caused by cellular stress. Nevertheless, due to intrinsic properties of NAD + e.g., high polarity and associated poor cell passage, these PTMs are difficult to...

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