Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling.

doi:10.1038/s41467-017-02244-2

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Article

Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling.

Nature communications - 16 Jan 2018

Elia Josephine, Ungal Grace, Kao Charlly, Ambrosini Alexander, De Jesus-Rosario Nilsa, Larsen Lene, Chiavacci Rosetta, Wang Tiancheng, Kurian Christine, Titchen Kanani, Sykes Brian, Hwang Sharon, Kumar Bhumi, Potts Jacqueline, Davis Joshua, Malatack Jeffrey, Slattery Emma, Moorthy Ganesh, Zuppa Athena, Weller Andrew, Byrne Enda, Li Yun R, Kraft Walter K, Hakonarson Hakon

Abstract excerpt

The glutamatergic neurotransmitter system may play an important role in attention-deficit hyperactivity disorder (ADHD). This 5-week, open-label, single-blind, placebo-controlled study reports the safety, pharmacokinetics and responsiveness of the metabotropic glutamate receptor (mGluR) activator fasoracetam (NFC-1), in 30 adolescents, age 12-17 years with ADHD, harboring mutations in mGluR network genes....

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PMID: 29339723
DOI: 10.1038/s41467-017-02244-2
PMCID: PMC5770454

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