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Article

Programmed induction of endoreduplication by DNA double-strand breaks in Arabidopsis.

Proceedings of the National Academy of Sciences of the United States of America - 14 Jun 2011

Adachi Sumiko, Minamisawa Kazunori, Okushima Yoko, Inagaki Soichi, Yoshiyama Kaoru, Kondou Youichi, Kaminuma Eli, Kawashima Mika, Toyoda Tetsuro, Matsui Minami, Kurihara Daisuke, Matsunaga Sachihiro, Umeda Masaaki

Abstract excerpt

Genome integrity is continuously threatened by external stresses and endogenous hazards such as DNA replication errors and reactive oxygen species. The DNA damage checkpoint in metazoans ensures genome integrity by delaying cell-cycle progression to repair damaged DNA or by inducing apoptosis. ATM and ATR (ataxia-telangiectasia-mutated and -Rad3-related) are sensor kinases that relay the damage signal to...

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Identifiers

PMID: 21613568
DOI: 10.1073/pnas.1103584108
PMCID: PMC3116379

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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