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Article

Identification of thioredoxin-interacting protein (TXNIP) as a downstream target for IGF1 action

16 Jan 2018

Abstract excerpt

Significance Insulin-like growth factor 1 (IGF1) plays an important role in the regulation of metabolism and growth. Epidemiological studies revealed that IGF1 deficiency is associated with cancer protection. Genomic analyses conducted on patients with Laron syndrome (LS), a rare form of dwarfism linked to mutation of the growth hormone receptor, identified thioredoxin-interacting protein (TXNIP) as a downstream...

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PMID: 29339473
DOI: 10.1073/pnas.1715930115

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Identification of thioredoxin-interacting protein (TXNIP) as a downstream target for IGF1 actionPMID 29339473Read ↗

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