Clinical and Echocardiographic Impact of Tafazzin Variants on Dilated Cardiomyopathy Phenotype in Left Ventricular Non-Compaction Patients in Early Infancy.

doi:10.1253/circj.CJ-18-0470

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Article

Clinical and Echocardiographic Impact of Tafazzin Variants on Dilated Cardiomyopathy Phenotype in Left Ventricular Non-Compaction Patients in Early Infancy.

Circulation journal : official journal of the Japanese Circulation Society - 25 Sept 2018

Hirono Keiichi, Hata Yukiko, Nakazawa Makoto, Momoi Nobuo, Tsuji Tohru, Matsuoka Taro, Ayusawa Mamoru, Abe Yuriko, Hayashi Tamaki, Tsujii Nobuyuki, Abe Tadaaki, Sakaguchi Heima, Wang Ce, Takasaki Asami, Takarada Shinya, Okabe Mako, Miyao Nariaki, Nakaoka Hideyuki, Ibuki Keijiro, Saito Kazuyoshi, Ozawa Sayaka, Nishida Naoki, Bowles Neil E, Ichida Fukiko

Abstract excerpt

BACKGROUND: Left ventricular non-compaction (LVNC) is a cardiomyopathy morphologically characterized by 2-layered myocardium and numerous prominent trabeculations, and is often associated with dilated cardiomyopathy (DCM). Variants in the gene encoding tafazzin (TAZ) may change mitochondrial function and cause dysfunction of many organs, but they also contribute to the DCM phenotype in LVNC, and the clinical and...

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PMID: 30122738
DOI: 10.1253/circj.CJ-18-0470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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