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Article

IgM Augments Complement Bactericidal Activity with Serum from a Patient with a Novel CD79a Mutation.

Journal of clinical immunology - 1 Feb 2018

Langereis Jeroen D, Henriet Stefanie S, Kuipers Saskia, Weemaes Corry M R, van der Burg Mirjam, de Jonge Marien I, van der Flier Michiel

Abstract excerpt

Antibody replacement therapy for patients with antibody deficiencies contains only IgG. As a result, concurrent IgM and IgA deficiency present in a large proportion of antibody deficient patients persists. Especially patients with IgM deficiency remain at risk for recurrent infections of the gastrointestinal and respiratory tract. The lack of IgM in the current IgG replacement therapy is likely to contribute to...

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Share to Agammaglobulinemia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29335801
DOI: 10.1007/s10875-017-0474-7
PMCID: PMC5840230

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