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Article

Temozolomide analog PMX 465 downregulates MGMT expression in HCT116 colorectal carcinoma cells

13 Jan 2018

Abstract excerpt

The efficacy of temozolomide (TMZ) treatment for cancers is currently limited by inherent or the development of resistance, particularly, but not exclusively, due to the expression of the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) in a significant proportion of tumors. We have found that TMZ analog C8-methyl imidazole tetrazine (PMX 465) displayed good anticancer activity against the...

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PMID: 29331023
DOI: 10.1002/jcb.26674

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