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Article

Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the HNF4A Gene

29 Mar 2007

Abstract excerpt

BACKGROUND: Macrosomia is associated with considerable neonatal and maternal morbidity. Factors that predict macrosomia are poorly understood. The increased rate of macrosomia in the offspring of pregnant women with diabetes and in congenital hyperinsulinaemia is mediated by increased foetal insulin secretion. We assessed the in utero and neonatal role of two key regulators of pancreatic insulin secretion by...

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Identifiers

PMID: 17407387
DOI: 10.1371/journal.pmed.0040118

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Related research

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Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the HNF4A GenePMID 17407387Read ↗

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Heterozygous Hnf1a Mutation in Mice Reveals Multiple Pathogenic Mechanisms of HNF1A-MODYSemantic proximity Read ↗

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The evolving course of HNF4A hyperinsulinaemic hypoglycaemia--a case series.Semantic proximity Read ↗

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Expanded Clinical Spectrum in Hepatocyte Nuclear Factor 1B-Maturity-Onset Diabetes of the YoungSemantic proximity Read ↗

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