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Article

Transient Disruption of Adenosine Signaling During Embryogenesis Triggers a Pro-epileptic Phenotype in Adult Zebrafish.

Molecular neurobiology - 1 Aug 2018

Menezes Fabiano Peres, Machado Torresini Felipe, Nery Laura Roesler, da Silva Rosane Souza

Abstract excerpt

Adenosinergic signaling has important effects on brain function, anatomy, and physiology in both late and early stages of development. Exposure to caffeine, a non-specific blocker of adenosine receptor, has been indicated as a developmental risk factor. Disruption of adenosinergic signaling during early stages of development can change the normal neural network formation and possibly lead to an increase in...

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PMID: 29327202
DOI: 10.1007/s12035-017-0850-6

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